Ram Gopal Varma has approached Lakshmi Prasanna Manchu to play the lead role in his next film Department which has Amitabh Bachchan, Sanjay Dutt and Rana Daggubati playing the role of police officers. She was spotted attending a photo-shoot in Mumbai for the role. Initial reports suggested that Kangana Ranaut would play the female lead, but sources say that RGV has not yet finalized the casting and keeping his options open.
Lakshmi Manchu has been looking after the film productions of her father Mohan Babu but played the role of an evil witch in Anaganaga O Dheerudu. The film did not do well at the box office, but she received critical acclaim for her role.
She graduated with Bachelors in Theater Oklahoma City University. She has acted in the American Television series Las Vegas and Desperate Housewives. She has also appeared in TV commercials for Toyota, AARP and Chevrolet.